Drug Discovery and Pre-Clinical Development

BRP staff provide statistical leadership for the pre-clinical drug discovery and development activities of the Division of Cancer Treatment and Diagnosis. Staff collaborates in the design and implementation of analytic tools to predict clinical activity against a molecular target based on in-vivo models and in-vitro tumor cell line screens. Staff collaborate in the design and analysis of early clinical trials of new anti-cancer therapies, with particular focus on the measurement of biologic effects associated with molecular targets. BRP staff also conduct research to develop more effective designs for pre-clinical studies and early clinical trials and provides advice to professional staff both within and outside of the NCI on the design and analysis of such studies.