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Biometric Research Program (BRP)
Last Updated: 11/22/16

Predictive Biomarkers in Phase II/III Clinical Trials

  • Biomarker Targeted Randomized Design
  • Targeted design randomizes only marker positive patients to treatment or control arm. Untargeted design does not measure marker and randomizes all who otherwise are eligible.

  • Biomarker Stratified Randomized Design
  • Stratified design randomizes both marker positive and negative patients.