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Biometric Research Program (BRP)

FOCR/NCI TMB Calibration Tool: tmbLab

Drs. Lisa McShane, Laura Yee, and Qian Xie

This package generates and applies a calibration model as described in Phase 2 of the Friends of Cancer Research (FOCR) tumor mutational burden (TMB) harmonization project. The software estimates a calibration curve with corresponding prediction limits to quantify the average relationship between WES and panel TMB assay values as well as variability around that curve. Intervals of uncertainty are also provided to accompany the corresponding WES-calibrated TMB values.

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Support: TMB.Project.Support@mail.nih.gov

Reference: Vega DM, Yee LM, McShane LM, et al. Aligning Tumor Mutational Burden (TMB) quantification across diagnostic platforms: Phase 2 of the Friends of Cancer Research TMB Harmonization Project. Annals of Oncology 2021. https://www.sciencedirect.com/science/article/pii/S0923753421044951

Last Updated: 10/8/2021