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Dr. Laura M. Yee

Mathematical Statistician, Biostatistics Branch


Research Interests

Diagnostic statistics, biomarkers in clinical trials, survival analysis


CV (Updated January, 2022)


Selected Recent Peer Reviewed Papers:

Vega DM, Yee LM, McShane LM, Williams PM, Chen L, Vilimas T, Fabrizio D, Funari V, Newberg J, Bruce LK, Chen SJ. Aligning Tumor Mutational Burden (TMB) quantification across diagnostic platforms: Phase 2 of the Friends of Cancer Research TMB Harmonization Project (2021). Annals of Oncology. 32(12): 1626-1636.

Williams PM, Forbes T, P. Lund S, Cole KD, He HJ, Karlovich C, Paweletz CP, Stetson D, Yee LM, Connors DE, Keating SM (2021). Validation of ctDNA Quality Control Materials Through a Precompetitive Collaboration of the Foundation for the National Institutes of Health. JCO Precision Oncology. 5: 910-20.

Krushkal J, Negi S, Yee LM, Evans JR, Grkovic T, Palmisano A, Fang J, Sankaran H, McShane LM, Zhao Y, O’Keefe BR (2021). Molecular Genomic Features Associated with in Vitro Response of the NCI‐60 Cancer Cell Line Panel to Natural Products. Molecular Oncology. 15(2): 381-406.

Godsey JH, Silvestro A, Barrett JC, Bramlett K, Chudova D, Deras I, Dickey J, Hicks J, Johann DJ, Leary R, Lee JSH, McMullen J, McShane L, Nakamura K, Richardson AO, Ryder M, Simmons J, Tanzella K, Yee L, Leiman LC, on behalf of the BloodPAC Consortium (2020). Generic Protocols for the Analytical Validation of Next-Generation Sequencing-Based ctDNA Assays: A Joint Consensus Recommendation of the BloodPAC's Analytical Variables Working Group. Clinical Chemistry. 66 (9): 1156-1166.

Yee LM, McShane LM, Freidlin B, Mooney MM, Korn EL (2019). Biostatistical and logistical considerations in the development of basket and umbrella clinical trials. The Cancer Journal. 25 (4): 254-263.

Yee LM, Lively TG, McShane LM (2018). Biomarkers in early phase trials: Fundamental issues. Bioanalysis. 10 (12): 933-44.

Yee LM and Chan KCG (2017). Nonparametric inference for the joint distribution of recurrent marked variables and recurrent survival time. Lifetime Data Analysis. 23 (2): 207-222.

Yee LM and Chan KCG (2015). Nonparametric inference for time-dependent incremental cost-effectiveness ratios. Statistics in Medicine. 34 (30): 4057-4069.



Dr. Laura Yee

Office Address:
Room 5W626
9609 Medical Center Dr
Rockville, MD 20850


Contact Information:
Tel: (240) 276-5654
Fax: (240) 276-7888
Email:laura.yee@nih.gov