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Dr. George Wright

Mathematical Statistician, Computational & Systems Biology Branch

Biosketch:

Dr. George W. Wright has been a member of the Biometric Research Program since he received his doctorate in Statistics from the University of Maryland in 2000. His primary work has been to develop molecular models of Non-Hodgkin's lymphoma in collaboration with the lab of Dr. Louis Staudt (CCR/NCI) and the Lymphoma/Leukemia Molecular Profiling Project (LLMPP). Over that time, he has gained extensive experience in the analysis of a large number of genomic platforms, and he has also co-authored numerous papers, resulting in his being recognized in 2019 as a Highly Cited Researcher by the Web of Science. Diagnostic tests he has developed include the MCL35 proliferation assay and the Lymphoma Subtyping Test (LST), both available from NanoString, as well as the LymphGen genomic subtyping algorithm.

Research Interests

Statistical methodology for high dimensional data genomic analysis
Cross platform translation of biomarkers
Molecular characterization of Lymphoma

CV (Updated January, 2023)

Selected Peer Reviewed Papers:

Wilson, W.H., et al., Effect of ibrutinib with R-CHOP chemotherapy in genetic subtypes of DLBCL. Cancer Cell, 2021. 39(12): p. 1643-1653

Wright, G.W., et al., A Probabilistic Classification Tool for Genetic Subtypes of Diffuse Large B Cell Lymphoma with Therapeutic Implications. Cancer Cell, 2020. 37(4): p. 551-+

Schmitz R, Wright GW, Huang DW, et al. Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma. N Engl J Med 2018;378(15):1396-1407.

Phelan JD, Young RM, Webster DE, et al. A multiprotein supercomplex controlling oncogenic signalling in lymphoma. Nature 2018;560(7718):387-391.

Mottok A, Wright G, Rosenwald A, et al. Molecular classification of primary mediastinal large B-cell lymphoma using routinely available tissue specimens. Blood 2018;132(22):2401-2405.

Scott DW, Abrisqueta P, Wright GW, et al. New Molecular Assay for the Proliferation Signature in Mantle Cell Lymphoma Applicable to Formalin-Fixed Paraffin-Embedded Biopsies. Journal of Clinical Oncology 2017;35(15):1668-+.

Yuan, J., et al., Identification of Primary Mediastinal Large B-cell Lymphoma at Nonmediastinal Sites by Gene Expression Profiling. American Journal of Surgical Pathology, 2015. 39(10): p. 1322-1330.

Wright, G.W., L.E. Dodd, and E.L. Korn, Inherent difficulties in nonparametric estimation of the cumulative distribution function using observations measured with error: Application to high-dimensional microarray data. Statistics and Its Interface, 2014. 7(1): p. 69-73.

Scott DW, Wright GW, Williams PM, et al. Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue. Blood 2014;123(8):1214-1217.

Lenz G, Wright G, Dave SS, et al. Stromal Gene Signatures in Large-B-Cell Lymphomas. New England Journal of Medicine 2008;359(22):2313-2323.

Dave, S.S., et al., Molecular diagnosis of Burkitt's lymphoma. New England Journal of Medicine, 2006. 354(23): p. 2431-2442.

Wright GW, Simon RM. A random variance model for detection of differential gene expression in small microarray experiments. Bioinformatics 2003;19(18):2448-2455.

Wright G, Tan B, Rosenwald A, et al. A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma. Proceedings of the National Academy of Sciences of the United States of America 2003;100(17):9991-9996.

Rosenwald A, Wright G, Chan WC, et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. New England Journal of Medicine 2002;346(25):1937-1947.

Web tools:

• LymphGen DLBCL genetic subtype classification tool
• Lymph2CX DLCBL cell-of-origin classification tool