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Biometric Research Program (BRP)

Dr. George Wright

Mathematical Statistician, Computational & Systems Biology Branch

Research Interests

Statistical methodology for high dimensional data genomic analysis
Cross platform translation of biomarkers
Molecular characterization of Lymphoma

CV (Updated January, 2021)

Selected Peer Reviewed Papers:

Wright, G.W., et al., A Probabilistic Classification Tool for Genetic Subtypes of Diffuse Large B Cell Lymphoma with Therapeutic Implications. Cancer Cell, 2020. 37(4): p. 551-+

Roschewski, M., et al., Inhibition of Bruton tyrosine kinase in patients with severe COVID-19. Science Immunology, 2020. 5(48)

Schmitz R, Wright GW, Huang DW, et al. Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma. N Engl J Med 2018;378(15):1396-1407.

Phelan JD, Young RM, Webster DE, et al. A multiprotein supercomplex controlling oncogenic signalling in lymphoma. Nature 2018;560(7718):387-391.

Mottok A, Wright G, Rosenwald A, et al. Molecular classification of primary mediastinal large B-cell lymphoma using routinely available tissue specimens. Blood 2018;132(22):2401-2405.

Scott DW, Abrisqueta P, Wright GW, et al. New Molecular Assay for the Proliferation Signature in Mantle Cell Lymphoma Applicable to Formalin-Fixed Paraffin-Embedded Biopsies. Journal of Clinical Oncology 2017;35(15):1668-+.

Yuan, J., et al., Identification of Primary Mediastinal Large B-cell Lymphoma at Nonmediastinal Sites by Gene Expression Profiling. American Journal of Surgical Pathology, 2015. 39(10): p. 1322-1330.

Wright, G.W., L.E. Dodd, and E.L. Korn, Inherent difficulties in nonparametric estimation of the cumulative distribution function using observations measured with error: Application to high-dimensional microarray data. Statistics and Its Interface, 2014. 7(1): p. 69-73.

Scott DW, Wright GW, Williams PM, et al. Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue. Blood 2014;123(8):1214-1217.

Lenz G, Wright G, Dave SS, et al. Stromal Gene Signatures in Large-B-Cell Lymphomas. New England Journal of Medicine 2008;359(22):2313-2323.

Dave, S.S., et al., Molecular diagnosis of Burkitt's lymphoma. New England Journal of Medicine, 2006. 354(23): p. 2431-2442.

Wright GW, Simon RM. A random variance model for detection of differential gene expression in small microarray experiments. Bioinformatics 2003;19(18):2448-2455.

Wright G, Tan B, Rosenwald A, et al. A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma. Proceedings of the National Academy of Sciences of the United States of America 2003;100(17):9991-9996.

Rosenwald A, Wright G, Chan WC, et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. New England Journal of Medicine 2002;346(25):1937-1947.

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Dr. George Wright

Office Address:
Room 5W108
9609 Medical Center Dr
Rockville, MD 20850

Contact Information:
Tel: (240) 276-6027
Fax: (240) 276-7888