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Biometric Research Program (BRP)

Dr. George Wright

Mathematical Statistician, Computational & Systems Biology Branch

Research Interests

Statistical methodology for high dimensional data genomic analysis
Cross platform translation of biomarkers
Molecular characterization of Lymphoma

Selected Peer Reviewed Papers:

Schmitz R, Wright GW, Huang DW, et al. Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma. N Engl J Med 2018;378(15):1396-1407.

Phelan JD, Young RM, Webster DE, et al. A multiprotein supercomplex controlling oncogenic signalling in lymphoma. Nature 2018;560(7718):387-391.

Mottok A, Wright G, Rosenwald A, et al. Molecular classification of primary mediastinal large B-cell lymphoma using routinely available tissue specimens. Blood 2018;132(22):2401-2405.

Scott DW, Abrisqueta P, Wright GW, et al. New Molecular Assay for the Proliferation Signature in Mantle Cell Lymphoma Applicable to Formalin-Fixed Paraffin-Embedded Biopsies. Journal of Clinical Oncology 2017;35(15):1668-+.

Scott DW, Wright GW, Williams PM, et al. Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue. Blood 2014;123(8):1214-1217.

Lenz G, Wright GW, Emre NCT, et al. Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways. Proceedings of the National Academy of Sciences of the United States of America 2008;105(36):13520-13525.

Lenz G, Wright G, Dave SS, et al. Stromal Gene Signatures in Large-B-Cell Lymphomas. New England Journal of Medicine 2008;359(22):2313-2323.

Shaffer AL, Wright G, Yang LM, et al. A library of gene expression signatures to illuminate normal and pathological lymphoid biology. Immunological Reviews 2006;210:67-85.

Wright GW, Simon RM. A random variance model for detection of differential gene expression in small microarray experiments. Bioinformatics 2003;19(18):2448-2455.

Wright G, Tan B, Rosenwald A, et al. A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma. Proceedings of the National Academy of Sciences of the United States of America 2003;100(17):9991-9996.

Rosenwald A, Wright G, Chan WC, et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. New England Journal of Medicine 2002;346(25):1937-1947.

Dr. George Wright

Office Address:
Room 5W108
9609 Medical Center Dr
Rockville, MD 20850

Contact Information:
Tel: (240) 276-6027
Fax: (240) 276-7888