Supplementary material to the publication in Clinical Epigenetics,

Association of expression of epigenetic molecular factors with DNA methylation and sensitivity to chemotherapeutic agents in cancer cell lines

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Table S14

Significant correlations of methylation of target probes with drug response in the 23 indidividual cancer categories with at least 10 cell lines, satisfying pFDR < 0.05 and |ρ| > 0.5

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HEADER LEGEND:
- Spearman ρ, Spearman correlation coefficient
- |ρ|, the absolute value of the Spearman correlation coefficient
- GMD with associated expression, gene affecting DNA methylation or demethylation, the expression of which was significantly associated with methylation of a particular probe with |ρ| > 0.5
- Target gene, the gene for which methylation of a particular probe was analyzed in the correlation
- Probe, the individual CpG probe, methylation of which was analyzed in the correlation with drug response
- Chromosome, chromosome on which the target gene is located
- Cytoband, chromosomal region where the target gene is located
- Sample size, number of cell lines with available data included in the correlation analysis
- Additional information about individual probes according to the Illumina Infinium HumanMethylation450K Beadchip manifest is also provided.

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Target gene	Probe	GMD with associated expression	Agent	Drug response data source	Cancer category	Spearman ρ (|ρ| > 0.5)	pFDR	Sample size	Chromosome	CytoBand	Coordinate	Gene Accesion	UCSC RefGene Group	UCSC CpG Islands Name	Relation to UCSC CpG Island	Phantom	DMR	Enhancer	HMM Island	Regulatory Feature Name	Regulatory Feature Group	DHS
Target gene	Probe	GMD with associated expression	Agent	Drug response data source	Cancer category	Spearman ρ	pFDR	Sample size	Chromosome	CytoBand	Coordinate	Gene Accesion	UCSC RefGene Group	UCSC CpG Islands Name	Relation to UCSC CpG Island	Phantom	DMR	Enhancer	HMM Island	Regulatory Feature Name	Regulatory Feature Group	DHS
Target gene	Probe	GMD with associated expression	Agent	Drug response data source	Cancer category	Spearman ρ (|ρ| > 0.5)	pFDR	Sample size	Chromosome	CytoBand	Coordinate	Gene Accesion	UCSC RefGene Group	UCSC CpG Islands Name	Relation to UCSC CpG Island	Phantom	DMR	Enhancer	HMM Island	Regulatory Feature Name	Regulatory Feature Group	DHS