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Supplementary resource for

Association of expression of epigenetic molecular factors with DNA methylation and sensitivity to chemotherapeutic agents in cancer cell lines

Authors: Suleyman Vural, Alida Palmisano, William C. Reinhold, Yves Pommier, Beverly A. Teicher, Julia Krushkal



The publication is available at: https://doi.org/10.1186/s13148-021-01026-4



Web resource developed by: Computational and Systems Biology Branch (Biometric Research Program, DCTD/NCI)



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  • Information about 645 cancer cell lines included in analysis
  • Table S1: Genes directly or indirectly involved in DNA methylation and demethylation which were included in analysis
  • Table S3: Significant correlations of GMD expression with drug response in the pancancer dataset satisfying |ρ| > 0.3 and pFDR < 0.05
  • Table S4: Significant strong trans- and cis-correlations of GMD expression with methylation of individual probes in the pancancer dataset satisfying p < 1.389 x 10-8 and |ρ| > 0.5
  • Table S5: Significant strong trans- and cis-correlations of GMD expression with methylation of target gene regions in the pancancer dataset satisfying pFDR < 0.05 and |ρ| > 0.5
  • Table S6: Numbers of cis- and trans-correlations of GMD expression with methylation of individual probes in the pancancer dataset satisfying p < 1.389 x 10-8 and |ρ| > 0.5
  • Table S7: Numbers of cis- and trans-correlations of GMD expression with methylation of gene regions in the pancancer dataset satisfying pFDR < 0.05 and |ρ| > 0.5
  • Table S8: Epigenome-wide Spearman correlations of GMD expression with methylation of individual probes satisfying p < 6.039 x 10-10 and |ρ| > 0.5 in 23 individual cancer categories with at least 10 cell lines
  • Table S9: Epigenome-wide Spearman correlations of GMD expression with methylation of gene regions satisfying pFDR < 0.05 and |ρ| > 0.5 in 23 indidividual cancer categories with at least 10 cell lines
  • Table S10: Numbers of cis- and trans-correlations of GMD expression with methylation of individual probes in the 23 indidividual cancer categories with at least 10 cell lines, satisfying p < 6.039 x 10-10 and |ρ| > 0.5
  • Table S11: Numbers of cis- and trans-correlations of GMD expression with methylation of gene regions in the 23 indidividual cancer categories with at least 10 cell lines, satisfying pFDR < 0.05 and |ρ| > 0.5
  • Table S12: Significant correlations of methylation of target probes with drug response in the pancancer dataset satisfying pFDR < 0.05 and a relaxed threshold of |ρ| > 0.4
  • Table S13: Significant correlations of methylation of target gene regions with drug response in the pancancer dataset satisfying pFDR < 0.05 and a relaxed threshold of |ρ| > 0.4
  • Table S14: Significant correlations of methylation of target probes with drug response in the 23 indidividual cancer categories with at least 10 cell lines, satisfying pFDR < 0.05 and |ρ| > 0.5
  • Table S15: Significant correlations of methylation of target gene regions with drug response in the 23 indidividual cancer categories with at least 10 cell lines, satisfying pFDR < 0.05 and |ρ| > 0.5

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