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Biometric Research Program (BRP)

Supplementary material to the publication in Clinical Epigenetics,

Association of expression of epigenetic molecular factors with DNA methylation and sensitivity to chemotherapeutic agents in cancer cell lines

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Table S13


Significant correlations of methylation of target gene regions with drug response in the pancancer dataset satisfying pFDR < 0.05 and a relaxed threshold of |ρ| > 0.4



HEADER LEGEND:
- Spearman ρ, Spearman correlation coefficient
- |ρ|, the absolute value of the Spearman correlation coefficient
- GMD with associated expression, gene affecting DNA methylation or demethylation, the expression of which was significantly associated with methylation of a particular gene region with |ρ| > 0.5
- Target gene, the gene for which methylation of a particular probe was analyzed in the correlation
- Target gene region, gene region whose methylation was analyzed in the correlation with drug response
- Cytoband, chromosomal region where the target gene is located
- Sample size, number of cell lines with available data included in the correlation analysis

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Target gene Region GMD Agent Data source Spearman pFDR Sample size Cytoband



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Target gene Region GMD with associated expression Agent Drug response data source Spearman ρ
(|ρ| > 0.4)
pFDR Sample size Cytoband
Target gene Region GMD with associated expression Agent Drug response data source Spearman ρ pFDR Sample size Cytoband
Target gene Region GMD with associated expression Agent Drug response data source Spearman ρ
(|ρ| > 0.4)
pFDR Sample size Cytoband