Biometric Research Program (BRP) staff ensure that all national therapeutic clinical trials sponsored by the National Cancer Institute utilize appropriate, reliable and efficient statistical designs. The staff represents the National Cancer Institute in the interim statistical monitoring of these trials and provides advice to investigators within and outside the NCI on the design and analysis of medical studies.

BRP staff provide statistical collaboration in the clinical trials of the intramural Center for Cancer Research in the areas of neuro-oncology, urologic oncology, radiation oncology and cancer prevention.

BRP staff conduct independent and collaborative research on the effects of new cancer treatments, and on improved statistical methodology for the evaluation of new treatments. The section also develops mathematical models for the design of treatment regimens for evaluation in clinical trials.

• Development of Accelerated Titration Designs for Phase I clinical trials.
• Development of Bayesian methods for the desi gn and analysis of 2 x 2 factorial trials, therapeutic equivalence trials and multiple endpoint trials.
• Development of novel designs for phase I/II development of tumor vaccines and cytostatic agents.
• Development of Bayesian sequential designs for monitoring efficacy and toxicity in phase II trials of drug combinations using historical controls.
• New methods for the analysis of quality of life data in clinical trials.
• Mathematical models of the relationship betw een chemotherapy schedules and dose intensities and effects.